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KMID : 0376219780150010071
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Chonnam Medical Journal
1978 Volume.15 No. 1 p.71 ~ p.80
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Influence of intraventricular morphine on the renal function of the rabbit.
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Abstract
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As it has been known that the renal function is under the regulatory influencesof central nervous system by way of various mediators and as it has recently been suggested that various endogenous morphine-like substances (endorphins) found to be existing in the brain play important physiological roles as a neurotransmitter, in changing the modality in the pain perception, behavior, salivation, etc., the renotropic effects of morphine administered directly into the lateral ventricle of the rabbit were investigated in this study.
Small doses of morphine (0.27 nM/kg=0.1pg/kg as hydrochloride) reduced the urine flow rate without any change in renal hemodynamics. Moderate doses (2.7 nM/kg) decreased renal blood flow as well as the urine flow rate, along with a tendency of transient natriuresis. Large doses (27 nM/kg) produced marked decrease in renal blood flow and glomerular filtration rate with ensuing antinatriuresis and antidiuresis. These changes were completely abolished by denervating the kidney. No changes of renal function, nor any change of blood pressure were observed when the agent was given intravenously ´ up to 27 nM/kg.
These observations indicate that morphine administered intraventricularly influences the renal function via nerve pathway, in addition to the liberation of ADH, and it was suggested that endorphines might play a role in the centermediated regulation of renal function.
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